International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 206-211
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Invivo Hemostatic Effect of Ankaferd Blood Stopper in Rat Major Renal Trauma Model: Controlled Trial of Novel Hemostatic Agent
Cankon GERMIYANOGLU1, Emre HURI1, Turgay AKGUL1, Ali AYYILDIZ1, Huseyin USTUN2
1Ankara Training and Research Hospital, 2. Urology Department, Ankara, TURKEY
2Ankara Training and Research Hospital, Pathology Department, Ankara, TURKEY
Keywords: Ankaferd blood stopper, Hemorrhage, Hemostasis
Ankaferd Bloodstopper (ABS) which is a medicinal product has been approved in the control of hemorrhage externally, dental surgery bleedings in Turkey to control the bleeding in renal trauma model was evaluated. Twelve Wistar rats were divided into two groups. Group I (GI),control, Group II (GII), study group. One cm2 tissue was resected. ABS solution was applied to resected area in study group. Standard suture was applied to control group. Bleeding time, number of ABS, live condition were evaluated. Histopathologic evaluations were completed. Mean time of bleeding control was 3.2 (2.4-3.6) min in GII, no difference with GI (p> 0.05). In GII, active hemostasis was provided. Mean number of ABS gout was 6.0 (5-8). Glomerular necrosis was detected with higher rate in GI compared with GII. Erythrocyte aggregation was confirmed in GII. Calcification was formed significantly in GI compared GII (p< 0.05). ABS could be an effective agent to stop active major bleeding in renal trauma model.
Cankon GERMIYANOGLU1, Emre HURI1, Turgay AKGUL1, Ali AYYILDIZ1, Huseyin USTUN2
1Ankara Training and Research Hospital, 2. Urology Department, Ankara, TURKEY
2Ankara Training and Research Hospital, Pathology Department, Ankara, TURKEY
Keywords: Ankaferd blood stopper, Hemorrhage, Hemostasis
Ankaferd Bloodstopper (ABS) which is a medicinal product has been approved in the control of hemorrhage externally, dental surgery bleedings in Turkey to control the bleeding in renal trauma model was evaluated. Twelve Wistar rats were divided into two groups. Group I (GI),control, Group II (GII), study group. One cm2 tissue was resected. ABS solution was applied to resected area in study group. Standard suture was applied to control group. Bleeding time, number of ABS, live condition were evaluated. Histopathologic evaluations were completed. Mean time of bleeding control was 3.2 (2.4-3.6) min in GII, no difference with GI (p> 0.05). In GII, active hemostasis was provided. Mean number of ABS gout was 6.0 (5-8). Glomerular necrosis was detected with higher rate in GI compared with GII. Erythrocyte aggregation was confirmed in GII. Calcification was formed significantly in GI compared GII (p< 0.05). ABS could be an effective agent to stop active major bleeding in renal trauma model.
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