International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 112-117
C-reactive Protein /Albumin Ratio Relationship in Testicular Cancer and Comparison with Non-Cancerous Patients: Another New and Meaningful Parameter

Alper COSKUN1, Utku CAN1, Cengiz CANAKCI1

Kartal Dr. Lutfi Kirdar City Hospital, Department of Urology, Isatnbul, Turkey

The testicular tumor is a disease frequently seen in the young population and can metastasize rapidly. C-reactive Protein/Albumin Ratio (CAR), which is known to increase in case of malignancy, may also be associated with the testicular tumor. The study was designed by comparing pathological subtype, stage, and cancer-free group. A total of 107 patients aged 18-61 years who were diagnosed with testicular tumors between 2018 and 2022 were retrospectively screened. Patients’s age, preoperative (pre-op) and postoperative(post-op) C-Reactive Protein (CRP), albumin, C-reactive Protein/Albumin Ratio (CAR), Neutrophil‐lymphocyte Ratio
(NLR), Platelet-lymphocyte Ratio (PLR) recorded. As the control group, 101 varicocelectomy patients aged 18-38 between 2017- 2022 were examined. Data were analyzed according to pathological diagnosis, stage, and control group. Pre-op CAR values of Tm patients were 0.477 and post-op 0.407. (p= 0.069) While the CAR value of tumor patients was 0.477, it was found to be 0.081 in the control group. (p= 0.000) The cut-off value for CAR was 0.069. Of the 54 patients in the mixed germ cell tumor (MGCT) group, 22 were embryonal carcinomas (EC). 56 of 99 patients were T1, and pre-op and post-op CAR values were insignificant (p= 0.125, p= 0.919). CAR is an important parameter higher in testicular tumor patients than in the non-cancerous group. There was no significant difference between CAR values according to pathological subtype, tumor stage, and lymph node metastasis status.