International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 008-013
The Prognostic Significance of Prognostic Nutritional Index in Diffuse Large B Cell Lymphoma Patients

Merih Reis ARAS1, Fatma YILMAZ1, Mesut TIGLIOGLU2, Bugra SAGLAM3, Busra YUZGENC4, Hacer Berna AFACAN OZTURK1, Umit Yavuz MALKAN5, Murat ALBAYRAK1

1Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Department of Hematology
2Gaziantep Ersin Arslan Training and Research Hospital, Department of Hematology
3Sanliurfa Mehmet Akif Inan Training and Research Hopsital, Department of Hematology
4Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Department of Internal Medicine
5Hacettepe University, Faculty of Medicine, Department of Hematology

Keywords: Diffuse large B cell lymphoma, Prognostic nutritional index, Albumin, Lymphocyte, Survival
The aim of the study was to determine the prognositc value of baseline prognostic nutritional index (PNI) in diffuse large B cell lympho- ma (DLBCL) patitens. A retrospective analysis was made of patients diagnosed with diffuse large B cell lymphoma in our department between January 2012- February 2022. Patiens treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and predniso- lone were included the study. A receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of PNI. The prognostic role of PNI and survival outcomes were evaluated. One hundred and one patients with a median age of 66 [20-86] were included the study. The cut-off value of PNI was 48.8. Patients divided into two groups according to the PNI cut-off value. Com- pared to the PNI-low group (PNI ≤ 48.8), the PNI-high group (PNI > 48.8) had a significantly better overall survival and progression-free survival (p< 0.030 and p< 0.11, respectively). PNI can be used as a simple and useful predictor of prognosis in DLBCL patients.