International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 080-087
PROGNOSTIC FACTORS IN NASOPHARINGCAL CARCINOMA
NİLGÜN ÖZBEK1, BARIŞ OKUMUŞ1, ŞABAN Ç. GÖKÇE1, MELEK COŞKUN1
19 Mayıs Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı
Keywords: nasopharyngeal carcinoma, prognostic factor, radiotherapy
Fifty-one nasopharyngeal carcinoma patients, treated between January 1993 - December 2000, were investigated retrospectively in regard to locoregional control time, distant metastasis free-survival and overall survival. Patient's gender, age, histologicgrade, T and N stage, stage according to TNM classification, presence of cranial nerve deficits, radiological findings, neoadjuvan chemotherapy, duration of treatment, total dose, treatment response were tested as prognostic factors. Locoregional control time, distant metastasis free-survival and overall survival rates were calculated with Kaplan-Meier method. A Cox regression analyses was applied to multivariate analyses. The estimated 5-year local-regional control rate, distant metastasis free-survival and overall survival were 53.74%, 64.70% and 35.82%. Histology, extend of nasal cavity, neoadjuvan chemotherapy, radiotherapy dose and response to treatment were significant prognostic factors of locoregional control time. Presence of cranial nerve deficits and response to treatment were significant factors of distant metastasis free-survival. Age, histology, presence of cranial nerve deficits and response to treatment were found to be related to overall survival. In conclusion, radiotherapy response effect the time of locoregional control, distant metastasis free-survival and overall survival directly. We suggested that the patients with poor prognostic factors may be treated more aggressive treatment rejime and may be followed up more frequently.
NİLGÜN ÖZBEK1, BARIŞ OKUMUŞ1, ŞABAN Ç. GÖKÇE1, MELEK COŞKUN1
19 Mayıs Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı
Keywords: nasopharyngeal carcinoma, prognostic factor, radiotherapy
Fifty-one nasopharyngeal carcinoma patients, treated between January 1993 - December 2000, were investigated retrospectively in regard to locoregional control time, distant metastasis free-survival and overall survival. Patient's gender, age, histologicgrade, T and N stage, stage according to TNM classification, presence of cranial nerve deficits, radiological findings, neoadjuvan chemotherapy, duration of treatment, total dose, treatment response were tested as prognostic factors. Locoregional control time, distant metastasis free-survival and overall survival rates were calculated with Kaplan-Meier method. A Cox regression analyses was applied to multivariate analyses. The estimated 5-year local-regional control rate, distant metastasis free-survival and overall survival were 53.74%, 64.70% and 35.82%. Histology, extend of nasal cavity, neoadjuvan chemotherapy, radiotherapy dose and response to treatment were significant prognostic factors of locoregional control time. Presence of cranial nerve deficits and response to treatment were significant factors of distant metastasis free-survival. Age, histology, presence of cranial nerve deficits and response to treatment were found to be related to overall survival. In conclusion, radiotherapy response effect the time of locoregional control, distant metastasis free-survival and overall survival directly. We suggested that the patients with poor prognostic factors may be treated more aggressive treatment rejime and may be followed up more frequently.