International Journal of Hematology and Oncology 2018, Vol 28, Num 4 Page(s): 011-018
The Effectiveness of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients with Malignant Peritoneal Mesothelioma: A Tertiary Center Experience

Bulent AKSEL1, Hanifi SAHIN2, Mustafa E. SARI2

1University of Health Sciences, Faculty of Medicine, Dr. Abdurrahman Yurtsalan Training and Research Hospital, Department of General Surgery
2University of Health Sciences, Faculty of Medicine, Zekai Tahir Burak Women’s Health Training and Research Hospital, Department of Gynecologic Oncology, Ankara, TURKEY

Keywords: Malignant mesothelioma, Cytoreductive surgery, Hyperthermic intraperitoneal chemotherapy, Survival, Mortality
In this study, we aimed to investigate the effect of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) procedures on overall survival (OS), morbidity, and mortality rates in patients with malignant peritoneal mesothelioma (MPM), an extremely rare tumor. Between January 2012 and March 2017, 21 patients who were diagnosed with a MPM and underwent CRS plus HIPEC were retrospectively analyzed. The median age was 60 (range, 18 to 80) years. Eighteen patients (76.2%) had a history of exposure to asbestos. The median follow-up was 17 months (range, 1 to 36 months). The median OS was 26 months. The rates of OS at 12, 24, and 36 months were 80%, 80%, and 40.5%, respectively. The perioperative mortality and morbidity rates were 4.8% and 33.3%, respectively. The 3-year survival rate was 93.8 % for patients treated with a CC 0 or 1 resection, whereas the median OS was 6 months for those treated with a CC 2 or 3 resection (p= 0.007). Age, gender, smoking status, asbestos exposure, pathological type, peritoneal cancer index (PCI), lymph node involvement, ascites, and cancer antigen (CA)-125 were not found to significantly influence the OS in univariate analysis (p> 0.05). A successful CRS plus HIPEC in selected patients with MPM seems to have beneficial effects on OS. In addition, our morbidity and mortality rates are consistent with the current literature.