International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 237-243
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Assessment of BAALC Gene Expression in Acute Myeloid Leukemia Patients Compared to Control Group in North-East of Iran
Hossein AYATOLLAHI1, Hossein RAHIMI2, Amir H. JAFARIAN1, Abolghasem ALLAHYARI3, Mohammad H. SADEGHIAN3, Mohammad R. KERAMATI1, Maryam SHEIKHI1,5, Nafiseh AMINI1, Mojgan AMIRPOUR4, Sepideh SHAKERI1, Seyyedeh F. SHAMS1, Afsane BAHRAMI5
1Mashhad University of Medical Sciences, Faculty of Medicine, Cancer Molecular Pathology Research Center, Mashhad, IRAN
2Mashhad University of Medical sciences, Faculty of Medicine, Department of Internal Medicine, Mashhad, IRAN
3Mashhad University of Medical Sciences, Faculty of Medicine, Department of Hematology and Blood Bank, Mashhad, IRAN
4Mashhad University of Medical Sciences, Hematology and Blood Banking, Mashhad, IRAN
5Mashhad University of Medical Sciences, Faculty of Medicine, Department of Modern Sciences and Technologie, Mashhad, IRAN
Keywords: Acute myeloid leukemia, BAALC, RT-PCR, Survival rate, Up-regulation, Down-regulation
Acute myeloid leukemia (AML) is recognized as one of the most common types of leukemia among adults. This condition is characterized by the uncontrolled proliferation of myeloid progenitors, affecting the normal function of different systems in the human body. Various factors such as genetic abnormalities, exposure to chemicals, and viruses can induce AML. Expression of NPM1, CEBPA, MN1, and BAALC genes is among important genetic factors affecting AML prognosis and diagnosis. The aim of this study was to assess amount of BAALC gene expression in AML patients and its relation to survival rate. This case-control study was performed at Mashhad University of Medical Sciences, Mashhad, Iran. 56 AML patients and 56 healthy individuals were participated in this research. The level of BAALC gene expression was assessed by real-time polymerase chain reaction (RT-PCR) method; GPI gene was used as the control. For statistical analysis, SPSS version 21 was applied. P-value less than 0.05 was considered statistically significant. In total, 55.3% and 44.7% of the participants were male and female, respectively. BAALC gene up- and down-regulation was reported in 28.6% and 71.4% of AML cases, respectively. BAALC gene expression and hematological parameters were significantly different between the two groups (p< 0.05). Based on the findings, the survival rate was estimated at 31 and 39 months in patients with BAALC up- and down-regulation, respectively. BAALC gene over expression could be considered as a predictive factor for poor prognosis and reduced survival in AML patients.
Hossein AYATOLLAHI1, Hossein RAHIMI2, Amir H. JAFARIAN1, Abolghasem ALLAHYARI3, Mohammad H. SADEGHIAN3, Mohammad R. KERAMATI1, Maryam SHEIKHI1,5, Nafiseh AMINI1, Mojgan AMIRPOUR4, Sepideh SHAKERI1, Seyyedeh F. SHAMS1, Afsane BAHRAMI5
1Mashhad University of Medical Sciences, Faculty of Medicine, Cancer Molecular Pathology Research Center, Mashhad, IRAN
2Mashhad University of Medical sciences, Faculty of Medicine, Department of Internal Medicine, Mashhad, IRAN
3Mashhad University of Medical Sciences, Faculty of Medicine, Department of Hematology and Blood Bank, Mashhad, IRAN
4Mashhad University of Medical Sciences, Hematology and Blood Banking, Mashhad, IRAN
5Mashhad University of Medical Sciences, Faculty of Medicine, Department of Modern Sciences and Technologie, Mashhad, IRAN
Keywords: Acute myeloid leukemia, BAALC, RT-PCR, Survival rate, Up-regulation, Down-regulation
Acute myeloid leukemia (AML) is recognized as one of the most common types of leukemia among adults. This condition is characterized by the uncontrolled proliferation of myeloid progenitors, affecting the normal function of different systems in the human body. Various factors such as genetic abnormalities, exposure to chemicals, and viruses can induce AML. Expression of NPM1, CEBPA, MN1, and BAALC genes is among important genetic factors affecting AML prognosis and diagnosis. The aim of this study was to assess amount of BAALC gene expression in AML patients and its relation to survival rate. This case-control study was performed at Mashhad University of Medical Sciences, Mashhad, Iran. 56 AML patients and 56 healthy individuals were participated in this research. The level of BAALC gene expression was assessed by real-time polymerase chain reaction (RT-PCR) method; GPI gene was used as the control. For statistical analysis, SPSS version 21 was applied. P-value less than 0.05 was considered statistically significant. In total, 55.3% and 44.7% of the participants were male and female, respectively. BAALC gene up- and down-regulation was reported in 28.6% and 71.4% of AML cases, respectively. BAALC gene expression and hematological parameters were significantly different between the two groups (p< 0.05). Based on the findings, the survival rate was estimated at 31 and 39 months in patients with BAALC up- and down-regulation, respectively. BAALC gene over expression could be considered as a predictive factor for poor prognosis and reduced survival in AML patients.
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