International Journal of Hematology and Oncology 2019, Vol 29, Num 2 Page(s): 185-192
RED BLOOD CELL OXIDANT/ANTIOXIDANT STATUS IN PATIENTS WITH LUNG CANCER AND PNEUMONIA

HÜSEYİN ÖZYURT1, İNCİLAY GÖKBULUT1, FİKRET ÖZUĞURLU1, NURHAN KÖKSAL1, SADIK SÖĞÜT1, ÖMER AKYOL1

Gaziosmanpasa University School of Medicine, Department of Biochemistry, TOKAT

Keywords: lung cancer, pneumonia, malondialdehyde, nitric oxide, superoxide dismutase, catalase, glutathione peroxidase
The aim of this study was to investigate the activities of antioxidant enzymes and the levels of nitric oxide (NO) and malondialdehyde (MDA) in erythrocytes of patients with lung cancer and pneumonia. Erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities as well as MDA and NO levels were measured spectrophotometrically in patients with lung cancer (n=15) and pneumonia (n=12) as well as healthy control subjects (n=14). Erythrocyte CAT and GSH-Px activities were found to be decreased in patients with lung cancer compared with pneumonia and control groups (p<0.0001). It was shown that there was an increase in SOD activity in patients with pneumonia compared to lung cancer (18%) and control groups (15%), but the difference was not statistically significant. Significant correlations were found between MDA and SOD (r=0.796, p<0.0001); between NO and SOD (r=0.759, p<0.001); and between SOD and CAT (r=-0.543, p<0.037) in the lung cancer group. These results suggest insufficient antioxidant enzyme activities in erythrocytes of patients with lung cancer that leads to increased oxidative stress and damage to vital cellular components such as DNA with malignant changes. Erythrocytes may reflect the oxidant/antioxidant changes in lung cancer. Results have shown positive correlations between erythrocyte NO and SOD, and MDA and SOD in both lung cancer and control groups.