International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 159-165
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Haemostatic and Histopathological Effects of Ankaferd Blood Stopper, on Penile Cavernosal Tissue in Rats
Turgay AKGUL1, Emre HURI1, Ali AYYILDIZ1, Huseyin USTUN2, Cankon GERMIYANOGLU1
1Ankara Training and Research Hospital, Department of Second Urology Clinic, Ankara, TURKEY
2Ankara Training and Research Hospital, Department of Pathology, Ankara, TURKEY
Keywords: Ankaferd Blood Stopper, Haemostasis, Penile fracture, Rat penis
Penile fracture is defined as a traumatic rupture of the tunica albuginea of the corpora cavernosa. The pathologic lesion is a tear of the outer longitudinal layer of the tunica albuginea resulting in hematoma, swelling, and skin discoloration. In this study, we aimed to investigate the effect of Ankaferd Blood Stopper (ABS) on the penile cavernosal tissue histopathologically and possible use as a haemostatic agent in penile cavernosal surgeries.
Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in thirty-two Wistar Albino rats and the rats were randomly assigned into four main groups, each group containing eight rats. In group A, ABS was only applied locally onto the incision region. In group P, the incision was primarily repaired. In group PA; ABS was applied onto the incision region following primary repair. In group C, the incision was not repaired and left to secondary healing. Three weeks later, all rats were sacrificed and penectomy was carried out. In group A, fibrosis was observed in 2 rats and this group seemed to be the best group according to cavernosal healing. Although there was no significant difference between control group and groups A and PA according to inflammation, group A and PA were better than primary repair group (p= 0.046). The presence of siderophages and red blood cell aggregation were only observed in group A and group PA.
ABS can be employed to use in cavernosal surgeries due to its haemostatic and anti-inflammatory properties. Erythrocyte aggregation confirmed haemostatic activity of ABS in penile tissue.
Turgay AKGUL1, Emre HURI1, Ali AYYILDIZ1, Huseyin USTUN2, Cankon GERMIYANOGLU1
1Ankara Training and Research Hospital, Department of Second Urology Clinic, Ankara, TURKEY
2Ankara Training and Research Hospital, Department of Pathology, Ankara, TURKEY
Keywords: Ankaferd Blood Stopper, Haemostasis, Penile fracture, Rat penis
Penile fracture is defined as a traumatic rupture of the tunica albuginea of the corpora cavernosa. The pathologic lesion is a tear of the outer longitudinal layer of the tunica albuginea resulting in hematoma, swelling, and skin discoloration. In this study, we aimed to investigate the effect of Ankaferd Blood Stopper (ABS) on the penile cavernosal tissue histopathologically and possible use as a haemostatic agent in penile cavernosal surgeries.
Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in thirty-two Wistar Albino rats and the rats were randomly assigned into four main groups, each group containing eight rats. In group A, ABS was only applied locally onto the incision region. In group P, the incision was primarily repaired. In group PA; ABS was applied onto the incision region following primary repair. In group C, the incision was not repaired and left to secondary healing. Three weeks later, all rats were sacrificed and penectomy was carried out. In group A, fibrosis was observed in 2 rats and this group seemed to be the best group according to cavernosal healing. Although there was no significant difference between control group and groups A and PA according to inflammation, group A and PA were better than primary repair group (p= 0.046). The presence of siderophages and red blood cell aggregation were only observed in group A and group PA.
ABS can be employed to use in cavernosal surgeries due to its haemostatic and anti-inflammatory properties. Erythrocyte aggregation confirmed haemostatic activity of ABS in penile tissue.
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