International Journal of Hematology and Oncology
2024, Vol 34, Num 1 Page(s): 134-139
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Frequency of Cytochrome 450 (CYP2C9 and CYP2C19) Genetic Polimorphisms in Patients with Colorectal Carsinoma
Murat BUYUKDOGAN1, M. Cem BORUBAN2, Mehmet ARTAC2, Sennur DEMIREL3
1Selçuk Üniversitesi Meram Tıp Fakültesi, Genetik Hastalıklar Tanı Merkezi, Konya, TURKEY
2Selçuk Üniversitesi Meram Tıp Fakültesi, Tibbi Onkoloji Bilim Dalı, Konya, TURKEY
3Selçuk Üniversitesi Meram Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Konya, TURKEY
Keywords: Colorectal carcinoma, Cytochrome P450, CYP2C9 and CYP2C19 Polymorphizm, Asbestos
Colorectal cancers are important health problems particularly in developed countries, are multifactorial diseases developing by the effects of both genetic and environmental factors. In this case-control study, we evaluated the relationship between colorectal carcinoma and gene polymorphizms of CYP2C9 and CYP2C19 which are the members of CYP2C subfamily playing important roles in the metabolism of endogenous and exogenous compounds, and also assessed other possible relations with carcinogens and drugs as well as many other risk factors such as smoking, alcohol, family history of cancer and asbestos exposure.
Eighty-five patients histopathologically diagnosed with colorectal carcinoma admitted to Departments of Medical Oncology and Surgery at Meram Medical Faculty and eighty-five healhty volunteers, who have no family history of cancer, were included in this study. Heterozygote and mutant genotypes of CYP2C9 and CYP2C19 genes were determined by CYP2C9*2, CYP2C9*3 and CYP2C19*2, CYP2C19*3 Mutation Detection Kits by Light Cycler Real Time Polymerase Chain Reaction. Results were statistically compared in these case-control subjects and odds ratios were used.
There were no significant differences between patients with colorectal carcinoma and control groups. However, asbestos exposure ratio in patients with colorectal carcinoma was significantly higher (p < 0.05) than control subjects. Therefore, asbestos exposure may be considered as a risk factor for colorectal carcinoma.
Murat BUYUKDOGAN1, M. Cem BORUBAN2, Mehmet ARTAC2, Sennur DEMIREL3
1Selçuk Üniversitesi Meram Tıp Fakültesi, Genetik Hastalıklar Tanı Merkezi, Konya, TURKEY
2Selçuk Üniversitesi Meram Tıp Fakültesi, Tibbi Onkoloji Bilim Dalı, Konya, TURKEY
3Selçuk Üniversitesi Meram Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Konya, TURKEY
Keywords: Colorectal carcinoma, Cytochrome P450, CYP2C9 and CYP2C19 Polymorphizm, Asbestos
Colorectal cancers are important health problems particularly in developed countries, are multifactorial diseases developing by the effects of both genetic and environmental factors. In this case-control study, we evaluated the relationship between colorectal carcinoma and gene polymorphizms of CYP2C9 and CYP2C19 which are the members of CYP2C subfamily playing important roles in the metabolism of endogenous and exogenous compounds, and also assessed other possible relations with carcinogens and drugs as well as many other risk factors such as smoking, alcohol, family history of cancer and asbestos exposure.
Eighty-five patients histopathologically diagnosed with colorectal carcinoma admitted to Departments of Medical Oncology and Surgery at Meram Medical Faculty and eighty-five healhty volunteers, who have no family history of cancer, were included in this study. Heterozygote and mutant genotypes of CYP2C9 and CYP2C19 genes were determined by CYP2C9*2, CYP2C9*3 and CYP2C19*2, CYP2C19*3 Mutation Detection Kits by Light Cycler Real Time Polymerase Chain Reaction. Results were statistically compared in these case-control subjects and odds ratios were used.
There were no significant differences between patients with colorectal carcinoma and control groups. However, asbestos exposure ratio in patients with colorectal carcinoma was significantly higher (p < 0.05) than control subjects. Therefore, asbestos exposure may be considered as a risk factor for colorectal carcinoma.
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