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Development of Multiple Myeloma in the Course of Chronic Lymphocytic Leukemia: Case Report

Özlem Ş. BALÇIK¹, Simten DAĞDA޲, Murat ALBAYRAK¹, Cumali EFE³, Osman YOKUŞ⁴, Funda CERAN¹, Gülsüm ÖZET¹, Mesude YILMAZ¹, Levent ALBAYRAK<sup>5

1</sup>Ankara Dr. A. Y. Onkoloji Eğitim ve Araştırma Hastanesi Hematoloji Kliniği, ANKARA
²Ankara Numune Eğitim ve Araştırma Hastanesi Hematoloji Kliniği, ANKARA
³Ankara Numune Eğitim ve Araştırma Hastanesi 4. İç Hastalıkları Kliniği, ANKARA
⁴Kayseri Eğitim ve Araştırma Hastanesi Hematoloji Kliniği, KAYSERİ
⁵Ankara Numune Eğitim ve Araştırma Hastanesi 1. Patoloji Kliniği, ANKARA

Keywords: Chronic lymphocytic leukemia, Multiple myeloma

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B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are chronic B cell malignancies originating from different phases of B cell development. They are rarely seen together. A 64 year-old male diagnosed with CLL was being followed up, bone marrow biopsy were performed after the devolopment of hyperglobulinemia and increased serum urea values. Bone marrow biopsy revealed an increase of 40% atypical plasma cell count and 35% lymphocyte count. Although no alkylating agent was used, additional development of MM clone to CLL is remarkable. This situation was seen very rarely in the literature. We aimed to present this case to be an instrument in the understanding of B cell oncogenesis in molecular level.

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