International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 201-207
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Glutathione S-Transferases CYP2C9 and CYP2C19 Polymorphisms in Turkish Children with Cancer
Öznur DÜZOVALI1, Lülüfer TAMER2, Nurcan A. ATEŞ3, Zekeriya BÜYÜKDERELİ1, Hatice YILDIRIM2, Bahar TAŞDELEN4, Esat YILGÖR1, Uğur ATİK2
1Mersin University, Faculty of Medicine, Departement of Pediatrics, MERSİN
2Mersin University, Faculty of Medicine, Departement of Biochemistry, MERSİN
3Mersin University, Faculty of Medicine, Departement of Medical Biology and Genetics, MERSİN
4Mersin University, Faculty of Medicine, Departement of Biostatistics, MERSİN
Keywords: Polymorphism, Glutathione S-transferases, Cytochrome P-450, Childhood cancer
We investigated the associations between GSTM1, GSTT1, GSTP1, CYP2C9, CYP2C19 polymorphisms and childhood cancer. Genotypes were analyzed with real-time PCR in 61 children with cancer and 157 healthy controls. Twenty nine of 61 patients were diagnosed of leukemia and 8 of lymphoma. The remaining patients had solid tumors.
GSTM1 null genotype was associated with an increased risk of leukemia and lymphoma (OR= 2.2, 95%CI= 1.1-4.6) (p= 0.03). Presence of at least one mutant allele of GSTP1 was related to an increased risk of solid tumor (OR= 3.3, 95%CI= 1.3-8.3) (p= 0.02). Moreover, CYP2C9*2 allele was a high risk for leukemia and lymphoma (p= 0.04).
In conclusion, GSTM1, GSTP1, and CYP2C9 polymorphisms may play a role in the development of childhood cancer.
Öznur DÜZOVALI1, Lülüfer TAMER2, Nurcan A. ATEŞ3, Zekeriya BÜYÜKDERELİ1, Hatice YILDIRIM2, Bahar TAŞDELEN4, Esat YILGÖR1, Uğur ATİK2
1Mersin University, Faculty of Medicine, Departement of Pediatrics, MERSİN
2Mersin University, Faculty of Medicine, Departement of Biochemistry, MERSİN
3Mersin University, Faculty of Medicine, Departement of Medical Biology and Genetics, MERSİN
4Mersin University, Faculty of Medicine, Departement of Biostatistics, MERSİN
Keywords: Polymorphism, Glutathione S-transferases, Cytochrome P-450, Childhood cancer
We investigated the associations between GSTM1, GSTT1, GSTP1, CYP2C9, CYP2C19 polymorphisms and childhood cancer. Genotypes were analyzed with real-time PCR in 61 children with cancer and 157 healthy controls. Twenty nine of 61 patients were diagnosed of leukemia and 8 of lymphoma. The remaining patients had solid tumors.
GSTM1 null genotype was associated with an increased risk of leukemia and lymphoma (OR= 2.2, 95%CI= 1.1-4.6) (p= 0.03). Presence of at least one mutant allele of GSTP1 was related to an increased risk of solid tumor (OR= 3.3, 95%CI= 1.3-8.3) (p= 0.02). Moreover, CYP2C9*2 allele was a high risk for leukemia and lymphoma (p= 0.04).
In conclusion, GSTM1, GSTP1, and CYP2C9 polymorphisms may play a role in the development of childhood cancer.
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