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Serum Levels of Gastrin, and Insulin-like Growth Factor (IGF-1) in Patients with Gastro-Esophageal Cancer

Haluk DÜLGER¹, Mustafa İZMİRLݲ, M. Ramazan ŞEKEROĞLU¹, Süleyman ALICI³, Süleyman ÖZEN⁴, Serpil ÖZCAN<sup>1

1</sup>Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, VAN
²Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, VAN
³Atatürk Eğitim ve Araştırma Hastanesi Onkoloji Kliniği, ANKARA
⁴Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, VAN

Keywords: Gastrin, IGF-1, Gastric cancer, Esophagus cancer

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Gastrin and insulin-like growth factor (IGF-1) seem to play a significant role in cell proliferation of mammalian. In this study, we were aimed at investigating the serum levels of gastrin and IGF-1 in patients with gastric cancer and esophagus cancer. In 68 patients with gastric (40 patients) and esophagus (28 patients) cancer and 30 healthy adults were measured serum levels of gastrin, IGF-1, CEA, CA 19-9, CA 125 and growth hormone. All these parameters have been increased in both cancer groups (gastric and esophagus) than those of control group and these increase were significantly for serum levels of gastrin, CEA, CA 125 and growth hormone (p<0.05). It is concluded that in patients with gastric and esophagus cancer a significant increase of serum gastrin can be found and increased gastrin levels play a role in gastric and esophageal carcinogenesis.

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