International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 082-086
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RADIATION-INDUCED OSTEOSARCOMA IN JUVENILE ANGIOFIBROMA: A CASE REPORT
Saadettin KILIÇKAP1, Sercan AKSOY1, Murat DİNÇER1, E. Arzu SAĞLAM2, Şuayib YALÇIN1
1Hacettepe Üniversitesi Onkoloji Enstitüsü Medikal Onkoloji Ünitesi, ANKARA
2Hacettepe Üniversitesi Tıp Fakültesi Patoloji Bölümü, ANKARA
Keywords: Juvenil angiofibroma, Radiotherapy, Secondary tumor, Osteosarcoma
Juvenil nasopharyngeal angiofibroma (JNA) is a highly vascular tumour, arising from the fibrovascular stroma on the posterolateral nasal wall. JNA can be treated surgically and/or with radiotherapy. Despite therapeutic intervention, these tumors mostly present with recurrences. Osteosarcoma is a malignant neoplasm usually involving long bones in young adults. Ionizing radiation is a risk factor for osteosarcoma, in which case it usually localizes within the radiation field. Radiation-induced osteosarcoma generally occurs after a latent period of 5 to 20 years. Its skull involvement is very rare.
Saadettin KILIÇKAP1, Sercan AKSOY1, Murat DİNÇER1, E. Arzu SAĞLAM2, Şuayib YALÇIN1
1Hacettepe Üniversitesi Onkoloji Enstitüsü Medikal Onkoloji Ünitesi, ANKARA
2Hacettepe Üniversitesi Tıp Fakültesi Patoloji Bölümü, ANKARA
Keywords: Juvenil angiofibroma, Radiotherapy, Secondary tumor, Osteosarcoma
Juvenil nasopharyngeal angiofibroma (JNA) is a highly vascular tumour, arising from the fibrovascular stroma on the posterolateral nasal wall. JNA can be treated surgically and/or with radiotherapy. Despite therapeutic intervention, these tumors mostly present with recurrences. Osteosarcoma is a malignant neoplasm usually involving long bones in young adults. Ionizing radiation is a risk factor for osteosarcoma, in which case it usually localizes within the radiation field. Radiation-induced osteosarcoma generally occurs after a latent period of 5 to 20 years. Its skull involvement is very rare.
Herein we report a patient with nasopharyngeal angiofibroma treated with radiotherapy, and later developed radiotherapy- induced osteosarcoma.
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