International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 096-098
DEVELOPMENT OF AML IN A PATIENT WITH WHO WAS IN COMPLETE REMISSION AFTER LIMITED STAGE SMALL CELL CARCINOMA OF THE LUNG
AHMET DİRİER1, ABDURRAHMAN IŞIKDOĞAN1, BİLGEHAN KARADAYI1
Dicle Üniv. Tıp Fak. Radyasyon Onkolojisi AD
Keywords: small cell lung cancer, acute myeloblastik leukemia, second primary cancer
Concomitant thoracic irradiation and cisplatin and etoposide has been started at a 62 years old male patient with limited stage small cell carcinoma of the lung. Complete remission was achieved clinically and radiologically after 46 Gy irradiation and 4 cycle chemotherapy and prophylactic cranial irradiation was also applied. The patient was on complete remission for more than 6 months when he complained of malasia and hemogram revealed pancytopenia. Diagnosis of acute myeloblastic cell leukemia (AML) was reached with blood smear and bone marrow aspiration biopsy. AML-M2 diagnosis was confirmed with flowcytometry. Chemotherapy with cytosin-arabinoside and idarubicin was started. The patient has died at the 35th day of therapy with acute respiratory arrest. Death was dedicated to intracranial hemorrhage which caused by thrombocytopenia.
AHMET DİRİER1, ABDURRAHMAN IŞIKDOĞAN1, BİLGEHAN KARADAYI1
Dicle Üniv. Tıp Fak. Radyasyon Onkolojisi AD
Keywords: small cell lung cancer, acute myeloblastik leukemia, second primary cancer
Concomitant thoracic irradiation and cisplatin and etoposide has been started at a 62 years old male patient with limited stage small cell carcinoma of the lung. Complete remission was achieved clinically and radiologically after 46 Gy irradiation and 4 cycle chemotherapy and prophylactic cranial irradiation was also applied. The patient was on complete remission for more than 6 months when he complained of malasia and hemogram revealed pancytopenia. Diagnosis of acute myeloblastic cell leukemia (AML) was reached with blood smear and bone marrow aspiration biopsy. AML-M2 diagnosis was confirmed with flowcytometry. Chemotherapy with cytosin-arabinoside and idarubicin was started. The patient has died at the 35th day of therapy with acute respiratory arrest. Death was dedicated to intracranial hemorrhage which caused by thrombocytopenia.