International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 063-066
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EFFICACY OF INTRAVENOUS ANTI-D THERAPY IN CHILDHOOD CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA
Ali BAY1, Ahmet F. ÖNER1, Murat DOĞAN1, Mehmet AÇIKGÖZ1, İmdat DİLEK2
1Yüzüncü Yıl Üniversitesi Tıp Fakültesi Pediatri Anabilim Dalı, VAN
2Yüzüncü Yıl Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, VAN
Keywords: Idiopathic Thrombocytopenic Purpura, Anti D, Child
In this study we examined eleven patients with chronic immune thrombocytopenic purpura (ITP) who received anti D retrospectively. All of the cases have Rh+ blood group and non-splenectomized. Anti D was given 30µg/kg/dose on 0, 1, 7, 14, 21, 28 days by intravenous infusion in one hour. Three of them (27%) had complete response, three of them (27%) had partial response, three of them (27%) had minor response, and two of them (18%) didn’t response. On following, only one patient who responded initially, had high trombocyte count over 1 year. The other patient’s trombocyte counts were decreased to the initial level within 1-3 months after the treatment. We did not observe any important side effect. In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.
Ali BAY1, Ahmet F. ÖNER1, Murat DOĞAN1, Mehmet AÇIKGÖZ1, İmdat DİLEK2
1Yüzüncü Yıl Üniversitesi Tıp Fakültesi Pediatri Anabilim Dalı, VAN
2Yüzüncü Yıl Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, VAN
Keywords: Idiopathic Thrombocytopenic Purpura, Anti D, Child
In this study we examined eleven patients with chronic immune thrombocytopenic purpura (ITP) who received anti D retrospectively. All of the cases have Rh+ blood group and non-splenectomized. Anti D was given 30µg/kg/dose on 0, 1, 7, 14, 21, 28 days by intravenous infusion in one hour. Three of them (27%) had complete response, three of them (27%) had partial response, three of them (27%) had minor response, and two of them (18%) didn’t response. On following, only one patient who responded initially, had high trombocyte count over 1 year. The other patient’s trombocyte counts were decreased to the initial level within 1-3 months after the treatment. We did not observe any important side effect. In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.
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