Back | Table of Contents | Turkish Abstract | PDF | Mail to Author |

PROGNOSTIC SIGNIFICANCE OF NF-κB IN UNRESECTABLE NON-SMALL CELL CARCINOMA OF THE LUNG TREATED WITH CONCOMITTANT CHEMORADIOTHERAPY

Celalettin EROĞLU¹, Işın SOYUER², Serdar SOYUER¹, Oğuz G. YILDIZ¹, Okan ORHAN¹, Mete GÜNDOй, Metin ÖZKAN³, Özlem ER³, Mustafa ALTINBA޳, Bünyamin KAPLAN<sup>1

1</sup>Erciyes Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı
²Erciyes Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı
³Erciyes Üniversitesi, Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, KAYSERİ

Keywords: NSCLC, Chemoradiotherapy, NF-κB, Prognostic factor

---

The aim of this study is to determine the prognostic value of transcription factor nucleer factor kappa B (NF-κB) in
unresectable non-small cell lung cancer (NSCLC) patients treated with concurrent chemoradiotherapy.

Twenty-eight unresectable NSCLC patients treated with concurrent chemoradiotherapy with paclitaxel + carboplatin were enrolled in this study. All patients received paclitaxel + carboplatin chemotherapy and radiotherapy concomittantly as primary treatment. Then patients received 0-4 cycles chemotherapy as a consolidation treatment. Immunohistochemistry was performed on paraffin embedded tissue. NF-κB monoclonal antibadies were used for the staining. The progression free survival and overall survival diference were analised between NF-κB positive and negative groups. For NF-κB a specimen was judged positive if more than 10% of the total cancer cells in a single field of view showed a response.

In patients who NF-xB was stained more than 10%, the disease free survival was better although there was not statistically significant difference. But in two groups, the overall survival was the same. NF-κB may be a useful prognostic factor in unresectable NSCLC patients.

Back | Table of Contents | Turkish Abstract | PDF | Mail to Author |