International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 052-060
FREE OXYGEN RADICALS, CARCINOGENESIS AND ANTIOXIDANT ENZYMES
AYSUN ÖZKAN1, KAYAHAN FIŞKIN1
Akdeniz Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, ANTALYA
Keywords: free oxygen radicals, antioxidant, carcinogenesis
Free oxygen radicals which are known molecules or atoms having one or more unpaired electrons, play an important role both at initiation and promotion of multistage carcinogenesis. These highly reactive compounds can act as initiators or promoters, activate procarcinogens, cause DNA damage, and alter the cellular antioxidant defense system. However, free radical scavengers which are shown to be anticarcinogens, function as the inhibitors at both initiation and promotion stage of carcinogenesis and protect the cells against oxidative damage.
AYSUN ÖZKAN1, KAYAHAN FIŞKIN1
Akdeniz Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, ANTALYA
Keywords: free oxygen radicals, antioxidant, carcinogenesis
Free oxygen radicals which are known molecules or atoms having one or more unpaired electrons, play an important role both at initiation and promotion of multistage carcinogenesis. These highly reactive compounds can act as initiators or promoters, activate procarcinogens, cause DNA damage, and alter the cellular antioxidant defense system. However, free radical scavengers which are shown to be anticarcinogens, function as the inhibitors at both initiation and promotion stage of carcinogenesis and protect the cells against oxidative damage.