International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 217-222
THE EFFECTS OF ORAL IRON TREATMENT ON LIPID PEROXIDATION AND ANTIOXIDANT ENZYME ACTIVITIES IN CHILDREN WITH IRON DEFICIENCY ANEMIA
BAHATTİN TUNÇ1, HABİBE G. ÖZEN1, NAMİK DELİBAŞ1, RECEP SÜTÇÜ1
Süleyman Demirel Üniversitesi Tıp Fakültesi, Pediatrik Hematoloji Bilim Dalı, Isparta
Keywords: antioxidants, children, iron deficiency anemia, oxygen free radicals
This study was planned to examine the changes in the lipid peroxidation and in the activities of Antioxidant enzymes with peroral iron therapy in children with iron deficiency anemia (IDA). Twenty one patients with iron deficiency anemia were enrolled in this study. The patients were given peroral ferrous iron (ferrosanol) for treatment of iron deficiency anemia. Twenty two healthy children whose hematological findings were normal ranges were selected as control group. Serum levels of malondialdehyde (MDA) and activities of Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase were measured in children with IDA before and after iron therapy. These values were compared to those of control group. There were no significant differences between values of before and after iron treatment in IDA group. Pre and post treatment serum levels of MDA in the IDA group were higher than those of control group. According to these results it was suggested that susceptibility of RBCs to lipid peroxidation in IDA was increased which may be play a role in the patogenesis of the anemia in IDA, and the using with proper dose of iron in iron deficiency states may not be induce extra oxidant stress. In addition it was thought that serum MDA levels could be use as a marker in the monitoring of the oxidant stress during the iron therapy.
BAHATTİN TUNÇ1, HABİBE G. ÖZEN1, NAMİK DELİBAŞ1, RECEP SÜTÇÜ1
Süleyman Demirel Üniversitesi Tıp Fakültesi, Pediatrik Hematoloji Bilim Dalı, Isparta
Keywords: antioxidants, children, iron deficiency anemia, oxygen free radicals
This study was planned to examine the changes in the lipid peroxidation and in the activities of Antioxidant enzymes with peroral iron therapy in children with iron deficiency anemia (IDA). Twenty one patients with iron deficiency anemia were enrolled in this study. The patients were given peroral ferrous iron (ferrosanol) for treatment of iron deficiency anemia. Twenty two healthy children whose hematological findings were normal ranges were selected as control group. Serum levels of malondialdehyde (MDA) and activities of Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase were measured in children with IDA before and after iron therapy. These values were compared to those of control group. There were no significant differences between values of before and after iron treatment in IDA group. Pre and post treatment serum levels of MDA in the IDA group were higher than those of control group. According to these results it was suggested that susceptibility of RBCs to lipid peroxidation in IDA was increased which may be play a role in the patogenesis of the anemia in IDA, and the using with proper dose of iron in iron deficiency states may not be induce extra oxidant stress. In addition it was thought that serum MDA levels could be use as a marker in the monitoring of the oxidant stress during the iron therapy.