International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 188-195
PROGNOSTIC FACTORS IN SOFT TISSUE SARCOMAS
MEHTAP DALKILIÇ ÇALIŞ1, ALPASLAN MAYADAĞLI1, OKTAY İNCEKARA1
Şişli Etfal Eğitim ve Araştırma Hastanesi, Radyasyon Onkolojisi Kliniği, İSTANBUL
Keywords: soft tissue sarcomas, prognostic factors, surgery, radiotherapy, chemotherapy.
In this study, patients that came to our clinic with soft tissue sarcoma have been investigated to determine prognostic factors retrospectively. One hundred fourty four patients have been followed up between the years 1990-2000. The average age is 43. 76 of the patients are male and 68 are female. The most often seen first is leiomyosarcoma (20%, n=29),2nd is malignant fibrous histiocytoma (15%,n=21),3rd is liposarcoma(12%,n=17). Of these patients 55 were stage IV (38%), 56 were stage III (39%) and 23 were stage I (23%). Factors effecting overall survival were found as: age (p=0.0029), stage (p=0,0000), lymph node involvement (p=0.0000), radiotherapy (p=0.0372) [postoperative p=(0.0000)], chemotherapy (neo-adjuvant or adjuvant (p=0.0000), MEID application as chemotherapy regime (p=0.0197), presence of metastasis (p=0.0001) and application of metastasectomy (p=0.0269); factors effecting recurrence were found as: histopathological type (p=0.0499), deeply embedded tumour (p=0.0366) and lymph node involvement (p=0.0000). Factors effecting metastasis were found as: histopathological type (p=0.0496), grade (p=0.0363) and location (p=0.0210).
MEHTAP DALKILIÇ ÇALIŞ1, ALPASLAN MAYADAĞLI1, OKTAY İNCEKARA1
Şişli Etfal Eğitim ve Araştırma Hastanesi, Radyasyon Onkolojisi Kliniği, İSTANBUL
Keywords: soft tissue sarcomas, prognostic factors, surgery, radiotherapy, chemotherapy.
In this study, patients that came to our clinic with soft tissue sarcoma have been investigated to determine prognostic factors retrospectively. One hundred fourty four patients have been followed up between the years 1990-2000. The average age is 43. 76 of the patients are male and 68 are female. The most often seen first is leiomyosarcoma (20%, n=29),2nd is malignant fibrous histiocytoma (15%,n=21),3rd is liposarcoma(12%,n=17). Of these patients 55 were stage IV (38%), 56 were stage III (39%) and 23 were stage I (23%). Factors effecting overall survival were found as: age (p=0.0029), stage (p=0,0000), lymph node involvement (p=0.0000), radiotherapy (p=0.0372) [postoperative p=(0.0000)], chemotherapy (neo-adjuvant or adjuvant (p=0.0000), MEID application as chemotherapy regime (p=0.0197), presence of metastasis (p=0.0001) and application of metastasectomy (p=0.0269); factors effecting recurrence were found as: histopathological type (p=0.0499), deeply embedded tumour (p=0.0366) and lymph node involvement (p=0.0000). Factors effecting metastasis were found as: histopathological type (p=0.0496), grade (p=0.0363) and location (p=0.0210).