International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 020-024
THE EFFECTS OF CISPLATIN ON THE KIDNEY METABOLISM: ROLE OF GINKGO BILOBA EXTRACT
H. RAMAZAN YILMAZ1, BÜNYAMİN IŞIK1, MUKADDES GÜLEÇ1, SADIK SÖĞÜT1, ÖMER AKYOL1
Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik AD, ISPARTA
Keywords: cisplatin, kidney, hexokinase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, malate dehydrogenase, gbe
In this study, we aimed to examine whether antitumour drug cisplatin affect the metabolism of the kidney and consequently causes kidney damage and, Ginkgo biloba extract prevents this damage in rats. The experimental groups were as follows: Control group, Cisplatin-treated group (Cisplatin), and a group treated with Cisplatin plus Ginkgo biloba extract (GBE). The Cisplatin and Cisplatin+GBE groups were treated intraperitoneally with a single dose of 7 mg/kg body weight sisplatin at 4th day of the treatment. GBE was administrated at a dose of 100 mg/kg body weight orally, three days before and seven days after the treatment with cisplatin in the cisplatin+GBE group. Kidney tissues were taken 7 day after the cisplatin administration. The activities of kidney hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) serum enzymes were determined in each sample. The results of the experiment demonstrated that HK, G6PD, LDH, and MDH activities were increased significantly in the cisplatin group compared with control group. HK and G6PD activities were increased significantly in the cisplatin group compared with control group. G6PD activity was increased significantly in the cisplatin+GBE group compared with cisplatin group, and LDH activity was decreased significantly in the cisplatin+GBE group compared with cisplatin group. From these results, it can be concluded that cisplatin may cause kidney damage through metabolic enzymes and, GBE may prevent damage caused by cisplatin.
H. RAMAZAN YILMAZ1, BÜNYAMİN IŞIK1, MUKADDES GÜLEÇ1, SADIK SÖĞÜT1, ÖMER AKYOL1
Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik AD, ISPARTA
Keywords: cisplatin, kidney, hexokinase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, malate dehydrogenase, gbe
In this study, we aimed to examine whether antitumour drug cisplatin affect the metabolism of the kidney and consequently causes kidney damage and, Ginkgo biloba extract prevents this damage in rats. The experimental groups were as follows: Control group, Cisplatin-treated group (Cisplatin), and a group treated with Cisplatin plus Ginkgo biloba extract (GBE). The Cisplatin and Cisplatin+GBE groups were treated intraperitoneally with a single dose of 7 mg/kg body weight sisplatin at 4th day of the treatment. GBE was administrated at a dose of 100 mg/kg body weight orally, three days before and seven days after the treatment with cisplatin in the cisplatin+GBE group. Kidney tissues were taken 7 day after the cisplatin administration. The activities of kidney hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) serum enzymes were determined in each sample. The results of the experiment demonstrated that HK, G6PD, LDH, and MDH activities were increased significantly in the cisplatin group compared with control group. HK and G6PD activities were increased significantly in the cisplatin group compared with control group. G6PD activity was increased significantly in the cisplatin+GBE group compared with cisplatin group, and LDH activity was decreased significantly in the cisplatin+GBE group compared with cisplatin group. From these results, it can be concluded that cisplatin may cause kidney damage through metabolic enzymes and, GBE may prevent damage caused by cisplatin.